A self-assembled nano-spray formulation for synergistic therapy of anti-inflammation and skin repair

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◆ 논문 초록 (Abstract)

Inflammatory skin disorders (ISDs), characterized by severe inflammation and impaired skin barrier functions, often requires persistent treatment due to chronic and relapsing natures. To address these issues, we developed a small-molecular self-assembled nanodrug (ECN) that is composed of natural epigallocatechin-3-gallate (EGCG) self-assembled with tripeptide collagen (CTP). By formulating a transdermal enhancer (cationic dendrimer) with ECN, the resulted dendrimers/ECN nanocomplex (DECN) can effectively penetrate into the skin layer, resulting in effective anti-inflammatory response and repair of skin-barrier functions. In animal models of ISDs, including atopic dermatitis (AD) and psoriasis, DECN showed remarkable skin penetration, with high level of drug deposition in the epidermal-dermal layer. By using a commercially available spray pump, DECN nanoparticles can be further translated into a spray formulation, which contributes to alleviating visible symptoms, skin lesions, and inflammatory progression of psoriasis and AD. This all-in-one spray nano-formulation offers an effective, safe, and convenient way for ISDs treatment.

◆ 원문 정보
저자: Pan Q, Zhang S, Yan X, Guo J, Li B et al.
저널: Asian J Pharm Sci
연도: 2025
DOI: 10.1016/j.ajps.2025.101067

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