Photosensitivity and Photodermatoses

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◆ 논문 초록 (Abstract)

Photosensitivity refers to an abnormal cutaneous response to ultraviolet (UV) radiation or visible light and encompasses a broad spectrum of disorders with distinct mechanisms and clinical implications. A practical clinical framework classifies photodermatoses into 5 major categories: 1. Idiopathic photodermatoses. 2. Exogenous-agent photodermatoses. 3. Endogenous-agent photodermatoses (notably porphyrias). 4. Photoexacerbated dermatoses. 5. Photosensitive genodermatoses . Many conditions are triggered primarily by ultraviolet A (UVA), which penetrates deeper into the skin and through window glass, whereas visible-light–driven disease is especially relevant in pigmentary disorders and certain photosensitive dermatoses, requiring tinted/iron-oxide strategies. Tinted sunscreens can be particularly beneficial for visible-light–associated photodermatoses because they can improve spectral coverage that conventional UV filters do not fully address. Photosensitivity may be episodic and benign (eg, seasonal idiopathic photodermatoses) or may signal risk of systemic disease (eg, systemic lupus erythematosus photosensitivity) and metabolic disorders (eg, porphyrias). Therefore, careful classification and evaluation are central to patient safety. In systemic lupus erythematosus, abnormal reactivity to both UV radiation and visible light can be observed during phototesting, supporting the clinical relevance of broader-spectrum avoidance and protection strategies in selected patients.

◆ 원문 정보
저자: Sathe NC, Gillespie E
저널: Dermatology Research (추정)
연도: 2026

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