Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity

이 페이지는 아래 학술 논문의 초록(Abstract) 전문을 제공합니다. 원문은 하단 링크에서 확인하세요.

◆ 논문 초록 (Abstract)

Intermittent fasting (IF) can lower body mass during obesity, but it is unknown why certain individuals lose less fat and more lean mass during IF. We hypothesized that hyperinsulinemia and an insulin-responsive adipocyte factor regulate the balance between fat and muscle loss. Chronic elevation of insulin led to higher adipose tissue mass, larger adipocytes, and lower muscle mass after 10 weeks of 5:2 IF in obese male mice. Chronic hyperinsulinemia lowered adipose tissue interferon regulatory factor 4 (IRF4). Whole-body or adipocyte-specific deletion of Irf4 resulted in higher adipose tissue mass and lower muscle mass after IF in obese male mice in two separate models of equal or reduced caloric intake during IF. Males living with obesity and higher blood insulin levels lost more lean mass after a 48-h fast. Therefore, hyperinsulinemia and lower adipocyte IRF4 alter nutrient partitioning to promote higher adipose retention and lower muscle preservation during IF during obesity.

◆ 원문 정보
저자: Marko DM, Conn MO, Cavallari JF, Neudorf H, Steele AP et al.
저널: Cell Rep
연도: 2026
DOI: 10.1016/j.celrep.2026.117023

PubMed 원문 보기 →   DOI 바로가기 →

🔗 이 논문을 인용한 글

• 아침 공복 운동, 지방은 태우고 근육은 지킬 수 있을까? 2026년 최신 연구 정리