The brain-skin connection: A narrative review of neuroendocrine and immune pathways
이 페이지는 아래 학술 논문의 초록(Abstract) 전문을 제공합니다. 원문은 하단 링크에서 확인하세요. ◆ 논문 초록 (Abstract) BACKGROUND: Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly...
이 페이지는 아래 학술 논문의 초록(Abstract) 전문을 제공합니다. 원문은 하단 링크에서 확인하세요.
◆ 논문 초록 (Abstract)
BACKGROUND: Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly understood. OBJECTIVE: To synthesize current evidence on brain-skin pathways, emphasizing key mediators and feedback loops that explain how stress exacerbates skin disease and vice versa. METHODS: A comprehensive search through August 25, 2025, using terms related to brain-skin communication, psychodermatology, and stress-related pathophysiology included both in-vivo and in-vitro animal and human studies. RESULTS: 159 articles were included and synthesized. Key findings highlight a bidirectional brain-skin axis involving the brain and pituitary, adrenal glands, peripheral nerves and skin. Stress triggers the brain and pituitary to release corticotropin-releasing hormone and adrenocorticotropic hormone; adrenal glands to secrete cortisol, catecholamines and androgens; and peripheral nerves to release neuropeptides such as Substance P and calcitonin gene-related peptide. These are implicated in skin inflammation while skin-derived mediators (cytokines, chemokines, neurotrophins) may disrupt and cross the blood-brain barrier, amplifying neuroinflammation, and psychiatric symptoms. Together, these form a self-sustaining feedback perpetuating both dermatologic and psychological disease. LIMITATIONS: Much of the mechanistic understanding is derived from animal models; high-quality human data remain limited. CONCLUSION: Understanding the brain-skin axis identifies therapeutic targets and guides future research on stress-related skin disease.
◆ 원문 정보
저자: Tan CC, Soh KV, Wang E, Choi EC
저널: JAAD Int
연도: 2026
DOI: 10.1016/j.jdin.2025.10.008
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