Effects of Autologous Blood-Derived Extracellular Vesicles on Skin Regeneration and Anti-Aging: A Clinical Study

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◆ 논문 초록 (Abstract)

INTRODUCTION: Autologous blood-derived extracellular vesicles (EVs) have gained attention as a novel therapeutic approach for skin rejuvenation. This study evaluates their efficacy in improving wrinkles, lifting, hydration, barrier function, tone, radiance, texture, and pore size in human subjects. AIM: This study aimed to evaluate the clinical efficacy of a single intradermal injection of autologous blood-derived EVs in improving multiple skin parameters, including wrinkle reduction, skin lifting, hydration, barrier function, tone, radiance, texture, and pore size, over a three-week period. METHODS: Twenty-five participants aged 40-59 underwent a single facial injection of autologous blood-derived EVs. Evaluations were conducted before treatment, 5 days post-treatment, and 3 weeks post-treatment using objective skin analysis tools and subjective self-assessment questionnaires. RESULTS: Statistically significant improvements (p < 0.05) were observed in wrinkle depth, skin lifting, hydration, elasticity, and barrier function at both 5-day and 3-week time points. Skin tone, radiance, texture, and pore size also improved significantly over the study period. Subjective self-assessments corroborated the instrumental findings, with a marked increase in participant-reported satisfaction. No adverse reactions or safety concerns were reported during the study. CONCLUSIONS: This study demonstrates the clinical efficacy and safety of autologous blood-derived EVs in facial rejuvenation, supporting their potential as a non-invasive cosmetic treatment.

◆ 원문 정보
저자: Kang H, Kim JH, Cho Y, Go D, Park J et al.
저널: J Cosmet Dermatol
연도: 2026
DOI: 10.1111/jocd.70574

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