Metformin attenuates metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for metabolic syndrome
이 페이지는 아래 학술 논문의 초록(Abstract) 전문을 제공합니다. 원문은 하단 링크에서 확인하세요. ◆ 논문 초록 (Abstract) AIMS: Mixed evidence exists on whether metformin adds to or attenuates the insulin-sensitising effects of exercise. To...
이 페이지는 아래 학술 논문의 초록(Abstract) 전문을 제공합니다. 원문은 하단 링크에서 확인하세요.
◆ 논문 초록 (Abstract)
AIMS: Mixed evidence exists on whether metformin adds to or attenuates the insulin-sensitising effects of exercise. To date, no studies have tested whether metformin differentially impacts exercise training intensity-mediated insulin sensitivity. We tested the hypothesis that metformin would blunt metabolic insulin sensitivity and carbohydrate oxidation in an intensity-based manner among adults with metabolic syndrome (MetS) risk. MATERIALS AND METHODS: In a double-blind, placebo-controlled trial, participants were randomised to low-intensity exercise plus placebo (~55% VO2max 5 days/week, LoEx + PL, n = 22) or metformin (2000 mg/day, LoEx + Met, n = 21) and high-intensity exercise plus placebo (~85% VO2max 5 days/week, HiEx + PL, n = 24) or metformin (HiEx + Met, n = 24) for 16 weeks. A 120-min euglycaemic-hyperinsulinemic clamp (40 mU/m2/min, 90 mg/dL) was conducted pre- and post-treatment to assess metabolic insulin sensitivity (M-value/insulin). Fasting and insulin-stimulated carbohydrate oxidation was also assessed using indirect calorimetry. Adipokines (leptin, high molecular weight (HWM), and total adiponectin) were measured at 0 and 120 min of the clamp. Aerobic fitness (VO2max) and body composition (DXA) were also analysed. RESULTS: HiEx + PL increased metabolic insulin sensitivity (p = 0.017) while HiEx + Met, LoEx + PL, or LoEx + Met did not. HiEx + PL also raised insulin-stimulated carbohydrate oxidation and decreased fat oxidation compared with LoEx + Met (both, p = 0.008). Increased metabolic insulin sensitivity related to reductions in fasting glucose (r = -0.41, p = 0.025), VO2max (r = 0.55, p = 0.002), fasting leptin (r = -0.54, p = 0.01), and weight loss (r = -0.60, p < 0.001) after exercise and placebo, but not exercise and metformin. CONCLUSIONS: Metformin attenuated metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for MetS.
◆ 원문 정보
저자: Malin SK, Heiston EM, Battillo DJ, Ragland TJ, Ballantyne A et al.
저널: Diabetes Obes Metab
연도: 2026
DOI: 10.1111/dom.70478
