The Effects of Time-Restricted Feeding and Exercise on Cardiometabolic Health in Sedentary Older Adults: A Randomized Controlled Trial

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◆ 논문 초록 (Abstract)

PURPOSE: Exploring preferable lifestyle habits (diet or/and exercise) is essential in improving cardiometabolic health among older adults, who represent the most sedentary than other age populations and generally suffer from cardiometabolic problems. This study aimed to determine the effects of long-term time-restricted feeding (TRF), exercise training, and their combination on comprehensive measures of cardiovascular functions and multiple auxiliary indicators, and to simultaneously evaluate side effects and adherence. METHODS: 56 sedentary participants (age: 57.6±2.2) were randomly assigned to control (CON; n=14), exercise (EX; n=14), TRF (n=14), and a combinational intervention (EX+TRF; n=14) group. Participants in each group were instructed to follow their assigned TRF or/and exercise protocol throughout an 8-week period. The primary outcomes were changes in cardiovascular functions. Secondary outcomes included changes in body composition, metabolic parameters, circulating biomarkers, eating habits, and nutrient intake. RESULTS: After 8 weeks, EX (n=11), TRF (n=11), and EX+TRF (n=14) produced significant increase in heart rate variability (HRV) than CON (n=11) (P<0.05); EX and EX+TRF also significantly improved flow mediated dilation (FMD) (P<0.05). TRF and EX+TRF significantly induced reductions in body fat percentage, lean mass, and total calorie consumption than CON (P<0.05); EX even induced significant increases in inflammatory biomarkers (P<0.05). Three interventions potentially caused adverse events but with no obvious difference; neither TRF nor EX did produce superior adherence than the other, but there was a lower compliance when counseling them both. CONCLUSIONS: Sedentary older adults could achieve cardiovascular health benefits by choosing either TRF or exercise lifestyle, with no obvious difference in adverse event and adherence.

◆ 원문 정보
저자: Peng L, Chen L, Xia J, Zhou J, Shi N et al.
저널: Med Sci Sports Exerc
연도: 2026
DOI: 10.1249/MSS.0000000000003962

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