The Role and Implications of Epidermal Dysfunction in the Pathogenesis of Inflammaging

이 페이지는 아래 학술 논문의 초록(Abstract) 전문을 제공합니다. 원문은 하단 링크에서 확인하세요.

◆ 논문 초록 (Abstract)

Inflammaging has long been linked to the pathogenesis of various aging-associated disorders, including cardiovascular disease, obesity, type 2 diabetes, and dementia. Yet, the origins of inflammaging remain unclear. Although inflammatory dermatoses such as psoriasis and atopic dermatitis predispose to the development of certain aging-associated disorders, suggesting a pathogenic role of cutaneous inflammation in these disorders, the great majority of aged humans do not have inflammatory dermatoses. Nonetheless, recent studies point to epidermal dysfunction as contributing to inflammaging, even in otherwise normal aged humans. Chronologically aged skin exhibits reduced stratum corneum hydration levels, delayed permeability barrier recovery, and an elevated stratum corneum pH, all of which can provoke and exacerbate cutaneous inflammation. Owing to the prolonged release of proinflammatory cytokines (including TNFα, IL-1β, and IL-6) from the epidermis into the circulation in response to these functional abnormalities, cutaneous inflammation can lead to extracutaneous inflammation, resulting in the downstream development of inflammaging and its accompanying disorders. In support of this concept, topical therapies that improve epidermal function can mitigate some aging-associated disorders, such as mild cognitive impairment. In this perspective, we discuss the link between epidermal dysfunction and inflammaging and highlight the potential management of inflammaging-associated sequelae by enhancing epidermal functions.

◆ 원문 정보
저자: Zhang J, Xia B, Wakefield JS, Elias PM, Wang X
저널: J Invest Dermatol
연도: 2025
DOI: 10.1016/j.jid.2024.09.025

PubMed 원문 보기 →   DOI 바로가기 →

🔗 이 논문을 인용한 글

• 피부 트러블과 체중 증가가 동시에? 피부장벽 손상이 보내는 몸의 신호