An exploratory assessment of regional cutaneous vasodilator responses to local heating in young and older females

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◆ 논문 초록 (Abstract)

OBJECTIVE: To explore regional differences and potential age effects in cutaneous vascular conductance (%CVCmax) during local heating in young and older females. METHODS: In 10 young (21.4 ± 3.4 years) and 10 older (69.8 ± 2.7 years) females, %CVCmax was assessed using laser-Doppler flowmetry at the chest, abdomen, forearm, and thigh during rapid, local skin heating. Local temperature was set at 34 °C during baseline and increased to 39 °C, then 42 °C in 30 min increments each. Differences in %CVCmax between and within age groups were evaluated at baseline, the initial vasodilator peak, and both the 39 °C and 42 °C heating plateaus. RESULTS: In young females, responses were similar across regions with the exception that %CVCmax was reduced for the abdomen across heating phases relative to other regions (all P < 0.040). In contrast, calf responses in older females were greater compared to other regions during the 39 °C plateau only (all P < 0.049). %CVCmax was greater at the abdomen during the 42 °C plateau (P = 0.022) for older females compared to young. Similarly, responses pooled across sites were significantly different (P = 0.035). CONCLUSION: In our exploratory study we observed regional differences for both young and older females, and the pattern of response and the heating phases where differences occurred varied. Further, no age-related differences in %CVCmax were observed apart from a marginally greater response for older females at peak heating of 42 °C. These findings highlight the need to disentangle the effects of sex and age in evaluating the vascular responses to heat and provide a critical foundation for sex-specific investigations into microvascular dysfunction.

◆ 원문 정보
저자: Li-Maloney C, McGarr GW, King KE, Fujii N, Amano T et al.
저널: J Therm Biol
연도: 2025
DOI: 10.1016/j.jtherbio.2025.104190

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